Cüneyt TÜRKEŞ Doç. Dr. - Eczacılık Fakültesi

Biyokimya AbD.

Cüneyt TÜRKEŞ, Doç. Dr.

Doç. Dr. Cüneyt TÜRKEŞ, Atatürk Üniversitesi Fen Fakültesi mezunudur. Lisans eğitimini tamamladıktan sonra 2010 yılında Atatürk Üniversitesi Fen Bilimleri Enstitüsü Kimya Anabilim Dalı Biyokimya Bilim Dalı’nda yüksek lisansını, 2016 yılında Atatürk Üniversitesi Fen Bilimleri Enstitüsü Kimya Anabilim Dalı Biyokimya Bilim Dalı’nda doktorasını tamamlamıştır. 2020 yılında Erzincan Binali Yıldırım Üniversitesi’nde doçentliğini almıştır. Türkeş’in, SCI indeksli dergilerde yayımlanmış 29 adet araştırma makalesi vardır. Ayrıca 2019 yılı Erzincan Binali Yıldırım Üniversitesi Akademik Bilim, Sanat ve Spor Ödülü almıştır.

Çalışma Alanları:

Enzimlerin Kromatografik Metotlarla Saflaştırılması, Karakterizasyonu ve Kinetik Özelliklerinin İncelenmesi, Enzim Genlerinin Klonlanarak Ekspresyonlarının Araştırılması, Antioksidan Moleküllerin Enzimler Üzerindeki Etkileri, İlaç-Enzim Etkileşmeleri

Makaleler

Askin, S., Tahtaci, H., Türkeş, C., Demir, Y., Ece, A., Çiftçi, G. A., & Beydemir, Ş. (2021). Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo [2, 1-b][1, 3, 4] thiadiazoles as highly potent acetylcholinesterase and non-classical carbonic anhydrase inhibitors. Bioorganic Chemistry, 105009.
Türkeş, C., Akocak, S., Işık, M., Lolak, N., Taslimi, P., Durgun, M., Gülçin, İ., Budak, Y., & Beydemir, Ş. (2021). Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors. Journal of Biomolecular Structure and Dynamics, 1-13.
Kalaycı, M., Türkeş, C., Arslan, M., Demir, Y., & Beydemir, Ş. (2021). Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors. Archiv der Pharmazie, 354(3), 2000282.
Akocak, S., Taslimi, P., Lolak, N., Işık, M., Durgun, M., Budak, Y., Türkeş, C., Gülçin, İ., & Beydemir, Ş. (2021). Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as α‐Glycosidase and Cholinesterase Inhibitors. Chemistry & Biodiversity, 18(4), e2000958.
Sever, B., Altıntop, M. D., Demir, Y., Türkeş, C., Özbaş, K., Çiftçi, G. A., Beydemir, Ş., & Özdemir, A. (2021). A new series of 2, 4-thiazolidinediones endowed with potent aldose reductase inhibitory activity. Open Chemistry, 19(1), 347-357.
Türkeş, C., Demir, Y., & Beydemir, Ş. (2021). Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes. Journal of Biomolecular Structure and Dynamics, 39(5), 1672-1680.
Sever, B., Türkeş, C., Altıntop, M. D., Demir, Y., & Beydemir, Ş. (2020). Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors. International Journal of Biological Macromolecules, 163, 1970-1988.
Kilic, A., Beyazsakal, L., Işık, M., Türkeş, C., Necip, A., Takım, K., & Beydemir, Ş. (2020). Mannich reaction derived novel boron complexes with amine-bis (phenolate) ligands: Synthesis, spectroscopy and in vitro/in silico biological studies. Journal of Organometallic Chemistry, 927, 121542.
Türkeş, C., Demir, Y., & Beydemir, Ş. (2020). Some calcium-channel blockers: kinetic and in silico studies on paraoxonase-I. Journal of Biomolecular Structure and Dynamics, 1-9.
Taslimi, P., Işık, M., Türkan, F., Durgun, M., Türkeş, C., Gülçin, İ., & Beydemir, Ş. (2020). Benzenesulfonamide derivatives as potent acetylcholinesterase, α-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies. Journal of Biomolecular Structure and Dynamics, 1-12.
Işık, M., Akocak, S., Lolak, N., Taslimi, P., Türkeş, C., Gülçin, İ., Durgun, M., & Beydemir, Ş. (2020). Synthesis, characterization, biological evaluation, and in silico studies of novel 1, 3‐diaryltriazene‐substituted sulfathiazole derivatives. Archiv der Pharmazie, 353(9), 2000102.
Lolak, N., Akocak, S., Türkeş, C., Taslimi, P., Işık, M., Beydemir, Ş., Gülçin, İ., & Durgun, M. (2020). Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1, 3, 5-triazine structural motifs. Bioorganic chemistry, 100, 103897.
Durgun, M., Türkeş, C., Işık, M., Demir, Y., Saklı, A., Kuru, A., Güzel, A., Beydemir, Ş., Akocak, S., Osman, S.M., AlOthman, Z., & Supuran, C. T. (2020). Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases. Journal of enzyme inhibition and medicinal chemistry, 35(1), 950-962.
Istrefi, Q., Türkeş, C., Arslan, M., Demir, Y., Nixha, A. R., Beydemir, Ş., & Küfrevioğlu, Ö. İ. (2020). Sulfonamides incorporating ketene N, S‐acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors. Archiv der Pharmazie, 353(6), 1900383.
Işık, M., Beydemir, Ş., Demir, Y., Durgun, M., Türkeş, C., Nasır, A., Necip, A., & Akkuş, M. (2020). Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies. International journal of biological macromolecules, 146, 1111-1123.
Işık, M., Demir, Y., Durgun, M., Türkeş, C., Necip, A., & Beydemir, Ş. (2020). Molecular docking and investigation of 4-(benzylideneamino)-and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors. Chemical Papers, 74(5), 1395-1405.
Demir, Y., Türkeş, C., & Beydemir, Ş. (2020). Molecular docking studies and inhibition properties of some antineoplastic agents against paraoxonase-I. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 20(7), 887-896.
Türkeş, C., & Beydemir, Ş. (2020). Inhibition of human serum paraoxonase-I with antimycotic drugs: in vitro and in silico studies. Applied biochemistry and biotechnology, 190(1), 252-269.
Gündoğdu, S., Türkeş, C., Arslan, M., Demir, Y., & Beydemir, Ş. (2019). New isoindole‐1, 3‐dione substituted sulfonamides as potent inhibitors of carbonic anhydrase and acetylcholinesterase: Design, synthesis, and biological evaluation. ChemistrySelect, 4(45), 13347-13355.
Türkeş, C., Beydemir, Ş., & Küfrevioğlu, Ö. İ. (2019). In vitro and in silico studies on the toxic effects of antibacterial drugs as human serum paraoxonase 1 inhibitor. ChemistrySelect, 4(33), 9731-9736.
Türkeş, C. (2019). A potential risk factor for paraoxonase 1: in silico and in‐vitro analysis of the biological activity of proton‐pump inhibitors. Journal of pharmacy and pharmacology, 71(10), 1553-1564.
Türkeş, C., Arslan, M., Demir, Y., Cocaj, L., Nixha, A. R., & Beydemir, Ş. (2019). Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors. Bioorganic chemistry, 89, 103004.
Beydemir, Ş., Türkeş, C., & Yalçın, A. (2019). Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies. Drug and chemical toxicology, 1-10.
Türkeş, C., Demir, Y., & Beydemir, Ş. (2019). Anti-diabetic properties of calcium channel blockers: inhibition effects on aldose reductase enzyme activity. Applied biochemistry and biotechnology, 189(1), 318-329.
Türkeş, C. (2019). Inhibition effects of phenolic compounds on human serum paraoxonase-1 enzyme. Journal of the Institute of Science and Technology, 9(2), 1013-1022.
Türkeş, C. (2019). Investigation of potential paraoxonase-I inhibitors by kinetic and molecular docking studies: chemotherapeutic drugs. Protein and peptide letters, 26(6), 392-402.

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Biyokimya AbD.

Cüneyt TÜRKEŞ, Doç. Dr.

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